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目的评价氟罗沙星和洛美沙星的体内外抗菌活性及临床疗效。方法采用琼脂平板稀释法测最低抑菌浓度（ＭＩＣ），微量稀释法测血清杀菌活性，观察两药对急性细菌性痢疾的临床疗效，并以氧氟沙星作对比。结果氟罗沙星和氧氟沙星对大肠杆菌、肺炎克雷白杆菌、痢疾杆菌及金黄色葡萄球菌的体外抗菌活性相似，其ＭＩＣ９０为０．２５～２ｍｇ／Ｌ，洛美沙星对上述菌的ＭＩＣ９０较氧氟沙星及氟罗沙星高２～４倍。氧氟沙星、氟罗沙星及洛美沙星对大肠杆菌、肺炎克雷白杆菌及痢疾杆菌的峰时血清杀菌活性≥１∶８的百分率分别为８０％～１００％、９０％～１００％和５０％～８０％。３种抗菌药物治疗急性细菌性痢疾各３０例的治愈率分别为１００％、１００％及９３．３％。结论与氧氟沙星相似，氟罗沙星对大肠杆菌、肺炎克雷白杆菌及痢疾杆菌具有较强的体外抗菌活性和体内杀灭作用，是治疗肠杆菌科感染的有效药物。洛美沙星对上述３种细菌的体外抗菌活性和体内杀灭作用略逊于氧氟沙星及氟罗沙星。
Objective To evaluate the antibacterial activity of fleroxacin and lomefloxacin in vitro and in vivo and its clinical efficacy. Methods The minimum inhibitory concentration (MIC) was determined by agar plate dilution method. The bactericidal activity of serum was measured by microdilution method. The clinical efficacy of the two drugs in treating acute bacillary dysentery was observed and compared with ofloxacin. Results Flevozacin and ofloxacin against E. coli, Klebsiella pneumoniae, Shigella and Staphylococcus aureus antibacterial activity in vitro similar MIC90 of 0.25 ~ 2mg / L, Lomefloxacin MIC90 2 ~ 4 times higher than ofloxacin and fleroxacin. The peak serum bactericidal activities of ofloxacin, fleroxacin and lomefloxacin against Escherichia coli, Klebsiella pneumoniae and Shigella dysenteriae were 80% -100%, 90% -100% and 50% respectively % ~ 80%. The cure rates of the three antibacterials in 30 cases of acute bacillary dysentery were 100%, 100% and 93.3% respectively. Conclusion Similar to ofloxacin, fleroxacin is an effective drug for the treatment of Enterobacteriaceae in Escherichia coli, Klebsiella pneumoniae and Shigella dysenteriae, which has strong in vitro antibacterial activity and in vivo killing effect. Lomefloxacin in vitro antibacterial activity of these three bacteria in vitro and in vivo killing effect slightly inferior to ofloxacin and fleroxacin.