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82只实验树鼩分为四组:A组26只,感染了HBV并同时给予AFB_1;B组34只,未感染HBV但给予AFB_1;C组13只,只感染了HBV;D组9只,既未感染HBV,又未接触AFB_1.实验158周.A组发生LCD16例(61.53%),其中9例发生HCC(56.25%).B组出现LCD18例(52.94%),其中3例发生HCC(16.66%).C组出现LCD 6例(46.15%);D组无LCD产生.82只树鼩有40只出现LCD,其中12只发生HCC(30%).而无LCD的42只,只有1例(C组)产生HCC(2.38%).LCD阳性组发生HCC的相对危险性为LCD阴性组的12.6倍.感染了HBV的树鼩,其LCD发生率显著高于未感染者(P<0.05);而在未感染HBV的动物中,摄入AFB_1的,其LCD发生率也同样比未摄入者高(P<0.05).表明HBV和AFB_1都能诱发LCD;LCD是HCC的癌前病变.
Twenty-two experimental tree cockroaches were divided into four groups: 26 in group A, infected with HBV and given AFB_1; 34 in group B, but not infected with HBV but given AFB_1; 13 in group C only infected with HBV; 9 in group D, Neither HBV infection nor AFB_1 exposure. Experiment 158 weeks. 16 cases of LCD in group A (61.53%), of which 9 cases of HCC (56.25%). Group B appeared 18 cases (52.94%), of which 3 cases of HCC ( 16.66%). There were 6 cases of LCD in group C (46.15%); no LCD was generated in group D. There were 40 LCDs with 82 tree shrews, and 12 HCCs (30%). There were 42 without LCDs, only 1 Cases (Group C) produced HCC (2.38%). The relative risk of developing HCC in the LCD-positive group was 12.6 times that of the LCD-negative group. The incidence of LCD was significantly higher in those infected with HBV than in those who did not (P<0.05). In the uninfected HBV-infected animals, the incidence of LCD in AFB_1 was also higher than that in the non-intake group (P<0.05). It indicated that both HBV and AFB_1 could induce LCD; LCD was precancerous lesion of HCC. .