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目的:观察宫腔镜检查诊断性刮宫术后加用妈富隆治疗围绝经期功能失调性子宫出血的临床效果。方法:将86例确诊为围绝经期功能性子宫出血患者进行药物治疗作为观察组,口服妈富隆1片/天,连续服用21天为1周期,3周期为1疗程。治疗前后均检测血常规、肝功能、卵泡刺激素、黄体生成素、雌二醇、孕酮、泌乳素和雄激素,术前均已行B超及妇科检查除外其他妇科病变。另取同时期本院就诊的仅行诊断性刮宫术确诊功血的患者56例作为对照组。结果:观察组86例患者治疗1疗程后,贫血得以纠正,停药后月经量恢复正常,治疗后血清E2、P平均水平较用药前下降明显,差异具有统计学意义(P<0.01),而FSH、LH、PRL、T用药前后变化不明显。结论:诊断性刮宫术后妈富隆治疗围绝经期功能失调性子宫出血效果好、不良反应小、复发率低,不易诱发其他激素依赖性疾病,是一种较好的药物治疗方案。
Objective: To observe the clinical effect of hysteroscopy combined with Marvelon in the treatment of dysfunctional uterine bleeding in perimenopausal women after diagnostic curettage. Methods: Eighty-six patients with functional uterine bleeding who were diagnosed as perimenopausal menstruation were selected as the observation group. Oral Marvelon was administered orally once daily for 21 days for one cycle and three cycles for one course of treatment. Before and after treatment were detected blood, liver function, follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, prolactin and androgen, have been preoperative B-and gynecological examination except for other gynecological lesions. Another take the same period only hospital diagnosis of dysfunctional uterine bleeding curettage 56 cases of patients as a control group. Results: In the observation group of 86 patients, the anemia was corrected after one course of treatment. The menstrual flow returned to normal after stopping treatment. The mean serum E2 and P levels decreased significantly after treatment (P <0.01), while the difference was statistically significant FSH, LH, PRL, T change was not obvious before and after treatment. Conclusion: After the diagnosis of curettage, Marvelon treatment of peri-menopausal dysfunctional uterine bleeding has a good effect, small adverse reactions, low recurrence rate, not easy to induce other hormone-dependent diseases, is a good drug treatment.