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通常认为药物的生物学作用是与血浆内非结合的药物浓度和浓度的维持时间成比例,此外还假定非结合的血药浓度和结合的能激活受体部分的药物浓度维持平衡,也即认为血浆药物浓度可反映药理效应。另方面
It is generally accepted that the biological effect of a drug is proportional to the concentration of plasma-unincorporated drug and the maintenance time of the plasma. In addition, it is assumed that the concentration of unbound plasma is balanced with the concentration of drug that binds to the active receptor. That is, Plasma drug concentration can reflect the pharmacological effects. The other side