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鼻部恶性肿瘤以鳞状细胞癌和腺癌多见,神经内分泌癌仅占5%.神经内分泌癌根据分化程度分为类癌(高分化)、不典型类癌(中分化)及小细胞癌(低分化)[1].低分化神经内分泌癌(PNEC)好发于50岁以上,人群中无性别差异,发病原因尚不明确,辐射和吸烟可能是危险因素,临床表现缺乏特异性,常见症状有鼻塞、鼻出血、面部疼痛及眼球突出,恶性程度高,预后差[2].延边大学附属医院于2015年
Nasal malignancy with squamous cell carcinoma and adenocarcinoma more common, neuroendocrine cancer accounted for only 5% .Neuroendocrine cancer according to the degree of differentiation into carcinoid (highly differentiated), atypical carcinoid (moderately differentiated) and small cell carcinoma (Poorly differentiated) .1 Poorly differentiated neuroendocrine carcinomas (PNECs) occur predominantly over the age of 50 with no gender differences in the population, the etiology of the disease is not clear, radiation and smoking may be risk factors, and the lack of specificity of clinical manifestations is common Symptoms are stuffy nose, nosebleeds, facial pain and prominence, high grade, poor prognosis.2 Yanbian University Hospital in 2015