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AIM:To investigate the expression of survivin during the early stages of hepatocellular carcinoma(HCC). METHODS:Immunohistochemical expression of survivin in liver tumor and non-tumor tissue specimens taken from 17 patients was compared.In addition,to determine the survivin expression in response to anti- cancer drugs in early stage HCC,the survivin expression was determined after the treatment of the HCC cells with anti-cancer drugs under hypoxic culture conditions. RESULTS:Survivin proteins were expressed in 64.7% of cells in early HCC specimens.A correlation between the survivin expression rate in the peritumoral hepatocytes and the rate of expression in the HCC specimens(low-rate group vs high-rate group)was observed.The survivin protein concentration in HCC cells was increased by the combination of hypoxia and anti-cancer drugs. CONCLUSION:This study suggests that survivin could be used as a therapeutic target in early HCC.
AIM: To investigate the expression of survivin during the early stages of hepatocellular carcinoma (HCC). METHODS: Immunohistochemical expression of survivin in liver tumor and non-tumor tissue specimens taken from 17 patients was compared. In addition, to determine the survivin expression in response to anti-cancer drugs in early stage HCC, the survivin expression was determined after the treatment of the HCC cells with anti-cancer drugs under hypoxic culture conditions. RESULTS: Survivin proteins were expressed in 64.7% of cells in early HCC specimens. A correlation between the survivin expression rate in the peritumoral hepatocytes and the rate of expression in the HCC specimens (low-rate group vs high-rate group) was observed. The survivin protein concentration in HCC cells was increased by the combination of hypoxia and anti- cancer drugs. CONCLUSION: This study suggests that survivin could be used as a therapeutic target in early HCC.