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目的运用Roc曲线通过与AFP比较评价a-L-岩藻糖苷酶(AFU)在原发性肝癌中的诊断价值,确定本实验室条件下的血清AFU用于诊断原发性肝癌的临界值,并比较AFU和AFP的筛查价值,为原发性肝癌的实验室诊断提供依据。方法对89例原发性肝癌,120例其他肝病及202名健康体检者,联合检测AFP和AFU,利用SPSS11.5统计软件绘制ROC曲线,通过比较这两种诊断试验的ROC曲线下面积来比较其诊断价值。结果ROC曲线下面积AFU为0.869,AFP为0.896,两者间差异有统计学意义。结论AFP的筛查价值略高于AFU,根据ROC曲线确定本实验室AFU临界值为32U/L。
Objective To compare the diagnostic value of aL-fucosidase (AFU) with primary AFP in the diagnosis of primary hepatocellular carcinoma using Roc curve and to determine the critical value of serum AFU for the diagnosis of primary liver cancer in this laboratory and compare AFU and AFP screening value for the diagnosis of primary liver cancer laboratory basis. Methods AFP and AFU were detected in 89 cases of primary hepatocellular carcinoma, 120 cases of other liver diseases and 202 healthy subjects. The ROC curve was drawn by using SPSS11.5 statistical software. By comparing the area under ROC curve of the two diagnostic tests Its diagnostic value. Results The area under ROC curve was 0.869 and AFP was 0.896, the difference was statistically significant. Conclusion The screening value of AFP is slightly higher than that of AFU. According to the ROC curve, the critical value of AFU in our laboratory is 32U / L.