论文部分内容阅读
鹽酸麻黄鹼溶液是常作为伤風感冒时治鼻塞用的,在医院中是配成1%的水溶液,处方中还常加有一些其他成分如緩冲剂等。由于鹽酸麻黄鹼水溶液在组織粘膜上吸收得很快,吸收后就与氨基氧化酶結合,于是就出现了与腎上腺素作用相似的微血管收縮作用。当我們用它来滴鼻时,若頻繁的重复使用,就会很快的产生耐受性,于是作用就漸漸地減弱了,最后甚至不起作用,必須經过一段停药时間后,才仍能恢复原来的作用,所以用它作滴鼻剂治鼻塞,就有这样的缺点。由于以上情况,我們想改变它的剂型,使它作用緩慢些,維持时間長些。我們採用的方法是將鹽酸麻黄鹼制成麻黄鹼;然后將它溶解在
Ephedrine hydrochloride solution is often used as a cold and flu treatment of nasal obstruction, in the hospital is dubbed 1% aqueous solution, the prescription often plus some other ingredients such as buffers and so on. Since ephedrine hydrochloride solution absorbs rapidly on the tissue mucosa, it binds to aminooxygenase after absorption, and thus microvascular vasoconstriction similar to that of epinephrine appears. When we use it to nasal drops, frequent re-use, it will quickly produce tolerance, so the effect gradually weakened, and finally did not work, you must go through a period of withdrawal, before Still be able to restore the original role, so use it as nose drops to cure nasal congestion, there is such a drawback. Because of the above, we want to change its dosage form, make it slower, and last longer. Our approach is to make ephedrine hydrochloride ephedrine; then dissolve it in it