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目的:探讨慢性肾功能衰竭病人血浆内毒素水平与肾脏损害程度的相关性。方法:测定血浆内毒素水平和血清肾功能生化指标尿素和肌酐的含量并进行相关分析。结果:慢性肾功能衰竭病人血浆内毒素水平显著高于健康对照者(P<0·01);内毒素水平与肾功能生化指标尿素、肌酐含量呈正相关,相关系数分别为0·806和0·814(P<0·01)。结论:内毒素血症是慢性肾衰患者常见并发症;高水平的内毒素可导致肾功能的损害,并促进肾功能衰竭。
Objective: To investigate the correlation between plasma endotoxin level and renal damage in patients with chronic renal failure. Methods: The levels of endotoxin in plasma and the biochemical indexes of serum renal function were measured and correlated. Results: The levels of plasma endotoxin in patients with chronic renal failure were significantly higher than those in healthy controls (P <0.01). The levels of endotoxin were positively correlated with the levels of urea, creatinine and renal biochemical markers, the correlation coefficients were 0.806 and 0.10 814 (P <0 · 01). CONCLUSIONS: Endotoxemia is a common complication in patients with chronic renal failure. High levels of endotoxin can cause impaired renal function and promote renal failure.