胺碘酮可引起甲状腺激素合成与分泌的暂时性减少,抑制外周组织 T_4转化为 T_3的过程,提高外周组织靶细胞对甲状腺激素作用的抵抗力。长期使用维持剂量的胺碘酮,可导致甲状腺功能失调-甲状隙机能减退或亢进。因为胺碘酮片(200mg)含无机碘75mg,几乎超过机体24h 需碘量的100倍,故能影响甲状腺的功能活动,但多数病例没有甲状腺功能失调的临床表现。使用胺碘酮头两周,常有血 T_4水平降低,但以后又升高,可能是由于胺碘 Amiodarone can cause temporary reduction of thyroid hormone synthesis and secretion, inhibit the process of transforming T_4 from peripheral tissue to T_3, and improve the resistance of target cells to thyroid hormone in peripheral tissues. Long-term use of maintenance doses of amiodarone can lead to thyroid dysfunction - hypothyroidism or hyperthyroidism. Because amiodarone tablets (200mg) contains inorganic iodine 75mg, almost more than 100 times the body needs 24-hour iodine, it can affect thyroid function activities, but most cases do not have the clinical manifestations of thyroid dysfunction. Amiodarone use the first two weeks, often lower blood T_4 levels, but later increased, probably due to amine iodine