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测定了20例充血性心力衰竭患者洋地黄治疗时的运动耐力,同时用侵入性方法测定其心指数及肺小动脉嵌压。其后改服国产氨利酮15天,重复测定上述指标。结果表明:患者运动耐受时间较用地高辛时明显延长;基础心指数及肺小动脉嵌压与运动耐受时间之间及用氨利酮后上述指标的增值之间缺乏相关性。提示国产氨利酮能改善充血性心衰患者的运动能力,但心功能的提高及肺嵌压的下降可能不是其主要机制。
The exercise endurance of digitalis in 20 patients with congestive heart failure was measured. The cardiac index and pulmonary arterial pressure were measured by invasive method. Subsequent domestic service aminopyrine 15 days, repeated measurements of the above indicators. The results showed that the exercise tolerance time of patients was significantly longer than that of digoxin. The correlation between basal cardiac index and arteriolar arterial pressure and exercise tolerance time and the increment of above indexes after using aminone was not correlated. It is suggested that domestic aminarin can improve the exercise capacity of patients with congestive heart failure, but the improvement of cardiac function and the decrease of pulmonary pressure may not be the main mechanism.