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目的观察分析在滴虫性阴道炎的治疗中甲硝唑和替硝唑不同给药途径的治疗效果。方法 184例滴虫性阴道炎患者,随机分为Ⅰ、Ⅱ、Ⅲ、Ⅳ组,各46例。Ⅰ组口服甲硝唑治疗,Ⅱ组口服替硝唑,Ⅲ组外用甲硝唑栓剂,Ⅳ组外用替硝唑栓剂。比较四组患者治疗1周后的疗效。结果Ⅰ组、Ⅱ组口服治疗总有效率分别为91.3%,97.8%;Ⅲ组、Ⅳ组外用栓剂治疗总有效率分别为54.3%,58.7%;Ⅰ组、Ⅱ组治疗总有效率显著高于Ⅲ组与Ⅳ组,差异均有统计学意义(P<0.05)。Ⅰ组不良反应发生率显著高于其他三组(P<0.05);而Ⅱ组不良反应不明显。结论采用甲硝唑和替硝唑口服治疗滴虫性阴道炎,疗效显著优于外用甲硝唑和替硝唑栓剂治疗疗效,因此在选择治疗有效药物时,应注意给药途径的有效性。
Objective To observe and analyze the therapeutic effect of different routes of administration of metronidazole and tinidazole in the treatment of trichomonas vaginitis. Methods 184 cases of trichomonas vaginitis were randomly divided into Ⅰ, Ⅱ, Ⅲ, Ⅳ group, each 46 cases. Group Ⅰ oral metronidazole treatment, oral tinidazole group Ⅱ, Ⅲ external metronidazole suppository, Ⅳ external tinidazole suppository. Four groups of patients were compared after 1 week of treatment. Results The total effective rates of oral administration in group Ⅰ and group Ⅱ were 91.3% and 97.8% respectively. The total effective rates of external suppositories in group Ⅲ and group Ⅳ were 54.3% and 58.7% respectively. The total effective rate in group Ⅰ and group Ⅱ was significantly higher than that in group Ⅱ and group Ⅱ Ⅲ and Ⅳ group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in group Ⅰ was significantly higher than that in the other three groups (P <0.05), while the adverse reactions in group Ⅱ were not obvious. Conclusion The treatment of trichomonas vaginitis with metronidazole and tinidazole orally is superior to topical metronidazole and tinidazole suppository. Therefore, we should pay attention to the effectiveness of the route of administration when choosing effective drugs.