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目的 探讨细胞周期蛋白D1(cyclinD1)和p16蛋白在肾母细胞瘤中的表达、相关性及其意义。方法 应用免疫组织化学方法检测 4 2例肾母细胞瘤患者组织中cyclinD1和 p16蛋白的表达情况。结果 4 2例中cyclinD1蛋白过表达率为 4 5 .2 3% ,p16蛋白表达缺失率为 6 9.0 4 % ,p16阳性表达与病理组织类型、患儿预后明显相关 (P <0 .0 1)阳性表达者预后好。结论 (1) p16 -cyclinD1- pRb通路异常与肾母细胞瘤的发病机制密切相关 ,(2 )cyclinD1过表达是肿瘤发生的早期事件 ,(3) p16蛋白表达可作为判断肾母细胞瘤预后的一项指标。
Objective To investigate the expression of cyclin D1 and p16 protein in Wilms’ tumor and its significance. Methods The expression of cyclinD1 and p16 proteins in 42 cases of Wilms’ tumor tissues were detected by immunohistochemistry. Results The overexpression rate of cyclinD1 in 42 cases was 45.23%, the deletion rate of p16 protein was 6 9.04%. The positive expression of p16 was significantly associated with the pathological type and prognosis (P <0.01) Positive expression of good prognosis. Conclusions (1) The abnormal p16-cyclinD1-pRb pathway is closely related to the pathogenesis of Wilms’ tumor. (2) The overexpression of cyclinD1 is an early event in tumorigenesis. (3) The expression of p16 protein can be used as a prognostic marker of nephroblastoma An indicator.