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目的:研究血纤维蛋白原及尿酸、白蛋白等指标与冠心病及其病变严重程度的关系。方法:将750例行冠状动脉造影的患者按造影结果分为冠心病组和对照组,用Gensini评分系统评价冠状动脉损害严重程度。采用多因素分析方法探讨冠心病及Gensini积分与血蛋白、尿酸、纤维蛋白原等因素的相关性。结果:冠心病组血白蛋白要显著低于正常对照组,血尿酸、纤维蛋白原要显著高于正常对照组;冠心病危险因素Logistic回归分析显示尿酸、纤维蛋白原等与冠心病独立相关;冠脉Gensini评分危险因素的多元逐步回归分析发现仅高血压史、纤维蛋白原与冠脉Gensini积分独立相关。结论:纤维蛋白原是冠心病的独立危险因素,也与冠心病严重程度独立相关。对于冠心病患者,应监测其纤维蛋白原、尿酸以及血清白蛋白含量。
Objective: To study the relationship between fibrinogen, uric acid and albumin and the severity of coronary heart disease and its pathological changes. Methods: 750 patients undergoing coronary angiography were divided into coronary heart disease group and control group according to the angiographic results. The severity of coronary artery lesion was evaluated by Gensini score system. The relationship between coronary heart disease and Gensini score and blood protein, uric acid, fibrinogen and other factors were investigated by multivariate analysis. Results: Serum albumin in CHD group was significantly lower than that in control group, serum uric acid and fibrinogen were significantly higher than those in control group. Logistic regression analysis of risk factors of CHD showed that uric acid and fibrinogen were independently associated with coronary heart disease. Multiple stepwise regression analysis of risk factors for coronary Gensini score revealed that in the history of hypertension alone, fibrinogen was independently associated with coronary Gensini scores. Conclusion: Fibrinogen is an independent risk factor for coronary heart disease and is independently related to the severity of coronary heart disease. For patients with coronary heart disease, their fibrinogen, uric acid, and serum albumin levels should be monitored.