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t(14;18)在滤泡型淋巴瘤的发病机制中起关键作用,它通过插入免疫球蛋白重链基因增强子而下调抗凋亡基因bc1-2的表达,约有1/3的原发性弥漫性大B细胞淋巴瘤(DLBCL)可发现t(14;18)(q32;q21)及bc1-2基因重排。但是,是否t(l4;18)代表了一种新的DLBCL亚型,以及它在DLBCL发病机制中的作用尚不清楚。最近发现2种DLBCL的亚型,一种具有正常B细胞生发中心即生发中心B细胞样(GCBL)表型,另一种具有活化的外周血B细胞表型即活化B细胞样(BCL)表型。作者检查了内布拉斯加州大学等医疗中心DLBCL患者的基因表达,以确定t(14;18)在其发病中的作用。
t (14; 18) plays a pivotal role in the pathogenesis of follicular lymphoma by down-regulating the expression of the anti-apoptotic gene bcl-2 by inserting the immunoglobulin heavy chain gene enhancer, approximately one-third of the original T (14; 18) (q32; q21) and bc1-2 gene rearrangements were found in patients with diffuse large B-cell lymphoma (DLBCL). However, whether t (l4; 18) represents a novel subtype of DLBCL and its role in the pathogenesis of DLBCL is unclear. Two DLBCL subtypes have recently been identified, one with a normal B cell germinal center known as the germinal center B cell-like (GCBL) phenotype and the other with an activated peripheral blood B cell phenotype known as the activated B cell-like (BCL) type. The authors examined the gene expression of patients with DLBCL in a medical center such as the University of Nebraska to determine the role of t (14; 18) in their pathogenesis.