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虽然有些研究指出急性心肌梗塞的发展与补体活化有关,但有关该病的补体变化的可靠证据报导甚少。作者对11例(男7,女4,平均年龄60.9±3.9岁)急性心肌梗塞病人,于发病后120小时内,连续检测血清总补体活性(CH50单位)、C_3、C_4和血清总蛋白含量。全部病人均有典型心肌梗塞病史和典型心电图及血清酶(CPK、GOT和LDH)的变化。病人均未接受特殊治疗(大量糖皮质激素或玻尿酸酶)。将出现典型胸痛的时间作为心肌梗塞发作的开始时间。每24小时采血一次。按Mayer的致敏绵羊红细胞的标准方法测定CH50单位;用单
Although some studies indicate that the development of acute myocardial infarction is associated with complement activation, reliable evidence for changes in complement in the disease is poorly documented. The authors tested the serum total complement activity (CH50 unit), C_3, C_4 and total serum protein in 120 acute myocardial infarction patients (male 7, female 4, average age 60.9 ± 3.9 years) within 120 hours after onset. All patients had a history of typical myocardial infarction and typical ECG and serum enzymes (CPK, GOT and LDH) changes. None of the patients received any special treatment (a large amount of glucocorticoid or hyaluronidase). The typical onset of chest pain occurs as the onset of a myocardial infarction. Blood sampling every 24 hours. CH50 units were determined by Mayer’s standard method for sensitized sheep erythrocytes;