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目的分析医院中药注射剂不良反应的发生情况,促进临床合理用药。方法收集2003年12月至2009年12月发生的中药注射剂不良反应发生病例,对其进行回顾性分析。结果共有218例由中药注射剂引起的不良反应,其中寒战、发热、皮疹等症状比较常见,新的不良反应达39.91%,参麦注射液和清开灵注射液是不良反应发生较多的药物,大部分药物不良反应对原患疾病的病情无明显影响,但未能找到发生严重不良反应的危险因素。结论中药注射剂不良反应的临床表现多样,新的不良反应较多;应关注常用中药注射剂的不良反应;使用不规范可能是中药注射剂不良反应发生的原因之一,建议对使用说明书作进一步的修改和完善。
Objective To analyze the occurrence of adverse reactions of hospital traditional Chinese medicine injections and promote the rational use of drugs in clinical practice. Methods The incidence of adverse reactions of traditional Chinese medicine injections from December 2003 to December 2009 was collected and retrospectively analyzed. Results A total of 218 adverse reactions caused by traditional Chinese medicine injections were reported. Among them, chills, fever, rash and other symptoms were common. The new adverse reactions were 39.91%. Shenmai injection and Qingkailing injection were the drugs with more adverse reactions. Most of the adverse drug reactions had no significant effect on the original disease, but failed to find the risk factors for serious adverse reactions. Conclusions The clinical manifestations of adverse reactions of traditional Chinese medicine injections are various and there are more new adverse reactions; the adverse reactions of commonly used Chinese medicine injections should be concerned; the use of nonstandard can be one of the reasons for the occurrence of adverse reactions of traditional Chinese medicine injections. It is recommended to further modify the instructions. perfect.