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目的观察2型糖尿病患者呼出气冷凝液(EBC)中亚硝酸盐(NO2-)的改变情况。方法选择16例2型糖尿病和20例健康非吸烟者,用Rtube收集器收集EBC,用NO检测试剂盒及分光光度法检测EBC中的NO2-浓度,同时检测肺功能。结果 2型糖尿病患者EBC中NO2-浓度高于健康对照组(P<0.01),两组肺功能第1秒用力呼气容积占预计值的百分比、CO肺弥散量占预计值的百分比比较均有统计学意义(P<0.05或0.01)。结论 NO2-在2型糖尿病患者肺功能损害发病中可能起重要作用。
Objective To observe the changes of nitrite (NO2-) in exhaled breath condensate (EBC) in type 2 diabetic patients. Methods Sixteen patients with type 2 diabetes and 20 healthy non-smokers were enrolled in the study. EBCs were collected with a Rtube trap, and NO2- concentration in EBC was detected by NO kit and spectrophotometry. Lung function was also measured. Results The NO2- concentration in EBC of patients with type 2 diabetes was higher than that of healthy controls (P <0.01). The percentage of 1-second forced expiratory volume of lung function in the two groups was the same as the predicted value Statistical significance (P <0.05 or 0.01). Conclusion NO2 - may play an important role in the pathogenesis of pulmonary dysfunction in type 2 diabetic patients.