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目的探讨加巴喷丁治疗尿毒症皮肤瘙痒的临床疗效及安全性。方法选取2012—2014年吉安县中医院收治的尿毒症皮肤瘙痒患者100例,随机分为观察组与对照组,各50例。对照组患者予以氯雷他定治疗,观察组患者予以加巴喷丁治疗。观察两组患者临床疗效、治疗前后瘙痒视觉模拟量表评分、匹茨堡睡眠质量指数评分及不良反应发生情况。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者瘙痒视觉模拟量表评分、匹茨堡睡眠质量指数评分比较,差异无统计学意义(P>0.05),治疗后观察组患者瘙痒视觉模拟量表评分、匹茨堡睡眠质量指数评分低于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论加巴喷丁治疗尿毒症皮肤瘙痒的临床疗效显著,可有效改善患者的临床症状及睡眠质量,且不良反应少,安全性高。
Objective To investigate the clinical efficacy and safety of gabapentin in the treatment of uremic skin pruritus. Methods 100 cases of uremic pruritus in Ji’an County Chinese Medicine Hospital from 2012 to 2014 were randomly divided into observation group and control group, 50 cases in each group. Patients in the control group were treated with loratadine, and patients in the observation group were treated with gabapentin. The clinical curative effect, pruritus visual analog scale score before and after treatment, Pittsburgh sleep quality index score and adverse reactions were observed. Results The total effective rate of the observation group was higher than that of the control group (P <0.05). There was no significant difference in the visual acuity scale of itching and Pittsburgh sleep quality index between the two groups before treatment P> 0.05). After treatment, the visual acuity scale of pruritus and the Pittsburgh sleep quality index in the observation group were lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups No statistical significance (P> 0.05). Conclusion The clinical efficacy of gabapentin in the treatment of uremic skin pruritus is remarkable, which can effectively improve the clinical symptoms and sleep quality of patients with less adverse reactions and high safety.