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乙型肝炎病毒(HBV)感染是目前世界上导致许多慢性肝脏疾病最常见的病因,HBV感染所致的慢性乙型肝炎(chronic hepatitisB,CHB)可以导致肝硬化以及肝细胞肝癌.Kupffer细胞是门脉系统的第一道屏障,也是机体固有免疫系统的重要组成部分,能通过表达TLR、FasL、PD-L1或者产生分泌大量的炎症因子、氧自由基和NO等,作用于HBV感染的肝细胞,在慢性HBV感染的免疫耐受和肝损伤过程中起着重要作用.
Hepatitis B virus (HBV) infection is by far the most common cause of many chronic liver diseases in the world, and chronic hepatitis B (CHB) caused by HBV infection can lead to cirrhosis and hepatocellular carcinoma.Kupffer cells The first barrier of the veins, which is also an important part of the body’s innate immune system, can act on HBV-infected hepatocytes by expressing TLR, FasL, PD-L1 or producing large amounts of inflammatory cytokines, oxygen free radicals and NO , Plays an important role in immune tolerance and liver damage in chronic HBV infection.