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氟哌酸(Narfloxacin)是一种新的喹诺酮类抗菌药物,通过抑制DNA旋转酶而杀菌。其杀菌活性由于氟化和接上哌嗪环而增强。抗菌谱也扩大,包括革蓝氏阴性菌(肠道细菌和假单胞菌)和一些革蓝氏阳性好气性细菌。这样使氟哌酸成为治疗尿路感染、淋病和细菌性肠炎选用的重要抗菌药性。虽然氟哌酸对其他感染病的疗效也有报道,但本文主要强调的是氟哌酸对上述疾病的疗效。
Narfloxacin, a novel quinolone antibacterial, is sterilized by inhibiting DNA gyrase. Its bactericidal activity is enhanced by fluorination and attachment of the piperazine ring. Antibacterial spectrum is also expanding, including Gram-negative bacteria (gut bacteria and Pseudomonas) and some Gram-positive aerobic bacteria. This makes norfloxacin an important antibacterial agent for the treatment of urinary tract infections, gonorrhea and bacterial enteritis. Although the efficacy of norfloxacin against other infectious diseases has also been reported, the main emphasis of this paper is on the efficacy of norfloxacin in these diseases.