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目的研究奥曲肽与泮托拉唑单独与联合治疗非静脉曲张性上消化道出血的有效性及安全性。方法选择2013年1月~2015年12月在延安大学附属医院进行诊治的非静脉曲张性上消化道出血患者162例,随机分为3组,每组54例。奥曲肽组给予奥曲肽单独治疗,泮托拉唑组给予泮托拉唑单独治疗,联合组给予奥曲肽与泮托拉唑联合治疗。比较3组的疗效、失血量、出血时间、血红蛋白水平和胃管引流液p H值。结果联合组的有效率为94.44%,明显高于奥曲肽组的75.93%和泮托拉唑组的77.78%(P<0.05);联合组的失血量和止血时间均明显低于奥曲肽组和泮托拉唑组(P<0.05),治疗后3组的血红蛋白水平均明显升高(P<0.05),且联合组明显高于奥曲肽组和泮托拉唑组(P<0.05);治疗后3组的胃管引流液p H值均明显升高(P<0.05),且联合组明显高于奥曲肽组和泮托拉唑组(P<0.05)。结论奥曲肽与泮托拉唑联合治疗非静脉曲张性上消化道出血的疗效明显由于单独治疗,安全有效,值得应用推广。
Objective To study the efficacy and safety of octreotide and pantoprazole alone and combined in the treatment of non-variceal upper gastrointestinal bleeding. Methods 162 patients with non-variceal upper gastrointestinal bleeding who were diagnosed and treated in Yan’an University Affiliated Hospital from January 2013 to December 2015 were randomly divided into 3 groups with 54 cases in each group. Octreotide group was treated with octreotide alone, pantoprazole group was given pantoprazole alone, the combination group was given octreotide and pantoprazole combination therapy. The curative effect, blood loss, bleeding time, hemoglobin and p H of gastric drainage were compared between the three groups. Results The effective rate of combination group was 94.44%, which was significantly higher than 75.93% of octreotide group and 77.78% of pantoprazole group (P <0.05). The blood loss and bleeding time in combination group were significantly lower than that of octreotide and pantophor (P <0.05). The levels of hemoglobin in the three groups were significantly increased after treatment (P <0.05), and the combined group was significantly higher than the octreotide and pantoprazole groups (P <0.05) (P <0.05). The combined group was significantly higher than octreotide and pantoprazole group (P <0.05). Conclusion The efficacy of octreotide in combination with pantoprazole in the treatment of non-variceal upper gastrointestinal bleeding is obviously safe, effective and worthy of promotion.