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目的报道7例颗粒细胞瘤并分析其误诊原因。方法分析这些病例的临床表现、形态学、免疫组织化学特征和预后。结果患者常为中年人,中位年龄47岁,病程较长,平均1.6年。肿瘤无恒定的发生部位,但好发于皮下或粘膜下。肿瘤质地较硬,大多数境界欠清楚,少数表面可伴有溃疡。病理学上肿瘤细胞大,胞质嗜酸性颗粒状,胞排列成条索或巢状。肿瘤S-100和NSE免疫染色均为100%(7/7)阳性。该类肿瘤绝大多数为良性,单纯手术切除即可治愈。结论因该瘤少见,临床无特征性,易误诊为其它肿瘤。病理学上需与胞质可出现颗粒性改变的肿瘤鉴别。
Objective To report 7 cases of granulosa cell tumor and analyze the causes of misdiagnosis. Methods The clinical manifestations, morphology, immunohistochemical features and prognosis of these cases were analyzed. Results Patients are often middle-aged, the median age of 47 years, longer duration, an average of 1.6 years. The tumor has no site of constant occurrence, but occurs subcutaneously or submucosally. Tumor texture is hard, most of the state is not clear, a small number of surfaces may be associated with ulcers. Pathological tumor cells, cytoplasmic eosinophilic granular cells arranged in a cord or nests. Tumor S-100 and NSE immunostaining were 100% (7/7) positive. Most of these tumors are benign, simple surgical excision can be cured. Conclusion Because of the rare tumor, no clinical features, easily misdiagnosed as other tumors. Pathological and cytoplasmic granules to be changed to identify the tumor.