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目的 研究人参 Rb组皂苷对犬实验性心肌缺血的保护作用。方法 通过结扎犬左冠状动脉前降支(L AD)产生急性心肌梗死模型 ,从心肌梗死面积 (MIS)及血清酶学变化观察人参 Rb组皂苷的抗心肌缺血作用 ,并从心肌代谢及自由基损伤等角度分析其可能的作用机制。结果 人参 Rb组皂苷 2 5 ,5 0 mg/kg经十二指肠给药 ,对L AD急性阻断 6 h犬 ,能明显缩小 MIS,降低血清肌酸磷酸激酶 (CK)及乳酸脱氢酶 (L DH )活性 ,亦能明显降低血清游离脂肪酸 (FFA)及过氧化脂质 (L PO)含量 ,提高超氧化物歧化酶 (SOD)活性。结论 人参 Rb组皂苷对急性缺血心肌产生明显保护作用 ,作用机制可能与其纠正心肌缺血时 FFA代谢紊乱及对抗氧自由基引发的脂质过氧化反应 ,增强体内抗氧化酶活性等有关
Objective To study the protective effect of ginsenoside Rb saponin on experimental myocardial ischemia in dogs. Methods The acute myocardial infarction model was established by ligation of the left anterior descending coronary artery (LAD) in dogs. The anti-ischemic effect of ginsenoside Rb saponin was observed from myocardial infarct size (MIS) and serum enzymology changes. Fundamental damage analysis of its possible mechanism of action. Results The ginseng Rb group saponin 25,50 mg/kg was administered by duodenum, and it can significantly reduce MIS and reduce serum creatine phosphokinase (CK) and lactate dehydrogenase. (L DH ) activity can also significantly reduce serum free fatty acid (FFA) and lipid peroxidation (L PO) levels and increase the activity of superoxide dismutase (SOD). Conclusion The ginsenoside Rb saponin can obviously protect the ischemic myocardium. The mechanism may be related to the correction of FFA metabolic disorder and anti-oxygen free radical-induced lipid peroxidation during myocardial ischemia, and enhance the activity of antioxidant enzymes in vivo.