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以１２５Ｉ标记的ＬＤＬＡＣＭ 复合物为示踪剂，研究了其在小鼠体内的药代动力学及组织分布。结果表明：小鼠单次尾静脉给药后的药代动力学符合二房室模型一级动力学，其药代动力学参数与天然ＬＤＬ相似；组织分布结果显示，尾静脉单次注入９０ｍｉｎ 后，ＬＤＬＡＣＭ 复合物在Ｈ２２ 荷瘤小鼠体内的分布顺序为肾上腺＞ 肝脏＞ 瘤组织＞ 脾和肾＞ 心和肺。与天然ＬＤＬ的分布基本一致。
The 125I-labeled LDL-ACM complex as a tracer, its pharmacokinetics and tissue distribution in mice. The results showed that the pharmacokinetics of mice after single tail vein administration conformed to the first-order kinetics of two-compartment model and the pharmacokinetic parameters were similar to those of natural LDL. The tissue distribution showed that after a single injection of tail vein for 90 minutes, LDL ACM complex in H22 tumor-bearing mice in the order of adrenal> liver> tumor> spleen and kidney> heart and lung. With the distribution of natural LDL basically the same.