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以125I标记的LDLACM 复合物为示踪剂,研究了其在小鼠体内的药代动力学及组织分布。结果表明:小鼠单次尾静脉给药后的药代动力学符合二房室模型一级动力学,其药代动力学参数与天然LDL相似;组织分布结果显示,尾静脉单次注入90min 后,LDLACM 复合物在H22 荷瘤小鼠体内的分布顺序为肾上腺> 肝脏> 瘤组织> 脾和肾> 心和肺。与天然LDL的分布基本一致。
The 125I-labeled LDL-ACM complex as a tracer, its pharmacokinetics and tissue distribution in mice. The results showed that the pharmacokinetics of mice after single tail vein administration conformed to the first-order kinetics of two-compartment model and the pharmacokinetic parameters were similar to those of natural LDL. The tissue distribution showed that after a single injection of tail vein for 90 minutes, LDL ACM complex in H22 tumor-bearing mice in the order of adrenal> liver> tumor> spleen and kidney> heart and lung. With the distribution of natural LDL basically the same.