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目的 :研究乳腺浸润性导管癌组织P2 7蛋白、ER、PR受体表达与病人预后的关系。方法 :用免疫组织化学EnvisionTM系统的二步法 ,检测乳腺浸润性导管癌组织P2 7蛋白、ER、PR受体表达 ,并与病人年龄、淋巴结转移及肿瘤体积大小等预后相关因素比较。结果 :乳腺浸润性导管癌P2 7蛋白表达与良性对照组比较 ,其差异有显著性 (P <0 0 5 ) ,并与预后呈正相关 ;与病人年龄 (≥ 5 0岁 )、淋巴结转移及瘤体大小 (≥ 2 5cm)呈负相关。结论 :P2 7蛋白、ER受体表达及淋巴结转移情况对乳腺浸润性导管癌的预后分析有重要参考价值。
Objective: To study the relationship between the expression of P27 protein, ER and PR receptors and the prognosis of patients with invasive ductal breast cancer. METHODS: Two-step immunohistochemical EnvisionTM system was used to detect the expression of P27 protein, ER, and PR receptors in invasive ductal carcinoma of the breast, and compared with the prognosis factors such as age, lymph node metastasis, and tumor size. Results: The expression of P27 protein in breast infiltrating ductal carcinoma was significantly different from that in the benign control group (P < 0.05) and positively correlated with the prognosis; it was related to the patient’s age (≥ 50 years), lymph node metastasis and tumors. Body size (≥ 25 cm) was negatively correlated. Conclusion : P27 protein, ER receptor expression and lymph node metastasis have important reference value for the prognostic analysis of invasive ductal carcinoma of the breast.