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目的 探讨O型血孕妇IgG抗体效价检测对新生儿溶血病(HND)的诊断价值.方法 选取2013年1月—2016年2月定期产前检查O型RhD阳性血型孕妇822例,检测孕妇血清IgG抗A(B)抗体效价,分析IgG抗A(B)抗体效价与HND的关系.结果 妊娠次数≥2次产妇IgG抗A(B)抗体阳性率和HDN发生率分别为54.05%和27.13%,均明显高于孕次为1次的产妇,差异有统计学意义(P<0.05);随着孕妇血清IgG抗A(B)抗体效价的增加,HDN发生率有增加的趋势(P<0.05),其中效价为1:512时HDN的发生率达到84.62%;IgG抗A(B)抗体效价与HDN患儿血清间接胆红素水平呈正相关(r=0.365,P<0.05).结论 母体IgG抗体效价在预测HDN发生中有一定的价值,且与患儿血清间接胆红素水平有关.“,”Objective To explore the diagnostic value of IgG antibody titer detection of O type pregnant women in hemolytic disease of the newborn (HND). Methods From January 2013 to February 2016, 822 cases of pregnant women with O type RhD positive who were examined regularly in our hospital were selected, to detect serum IgG anti A (B) antibody titer in pregnant women and to analyse the relationship between IgG anti A (B) antibody titer and HND. Results IgG anti A(B) antibody positive rate in pregnancy ≥ 2 times maternal and HDN incidence rate were 54.05% and 27.13%, significantly higher than those of pregnancy 1 time, the difference was statistically significant (P<0.05); With the increase of IgG anti A (B) antibody titer in pregnant women, the incidence of HDN was increased (P<0.05), the occurrence rate of HDN in titer 1:512 was 84.62%; The titer of IgG anti A (B) antibody was positively correlated with serum indirect bilirubin level in HDN (r=0.365, P<0.05). Conclusion Maternal IgG antibody titer has a certain value in predicting the occurrence of HDN, and is related to the level of indirect bilirubin in the serum of HDN children.