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Clark等(1980)描述了小鼠自发流产的动物模型,即CBA/J雌鼠与DBA/2J雄鼠交配后,胎鼠吸收率增加。Chaouat等(1983)发现给雌鼠免疫BALB/c雄鼠脾细胞可减少生殖失败率。这种保护作用与抗体的形成有关,此抗体是特异性地针对由主要组织相容性复合体和次要组织相容性位点所控制的抗原。胎鼠吸收率近来已作为重要的指标,用来评价主动和被动免疫的保护作用。根据暴露子宫腔的形态学特点判断妊娠的结局,吸收的胎鼠较活胎显著性减小并常有出血表现,高吸收率发生在孕10～13天。尽管子宫吸收可依据形态学来确定,但
Clark et al. (1980) described an animal model of spontaneous abortion in mice where the rate of fetal rat absorption increased after mating between male and female DBA / 2J males. Chaouat et al. (1983) found that immunization of female mice with splenocytes from BALB / c male mice can reduce the rate of reproductive failure. This protective effect is associated with the formation of antibodies that are specifically directed against the antigen that is controlled by the major histocompatibility complex and the minor histocompatibility site. Recently, fetal rat absorption has been used as an important indicator to evaluate the protective effects of active and passive immunity. According to the morphological characteristics of the uterine cavity to determine the outcome of pregnancy, the fetus than live vividly reduced significantly reduced and often bleeding performance, high absorption occurred in 10 to 13 days of pregnancy. Although uterine absorption can be determined by morphology,