流产是世界上妇女死亡的重要原因,因此急需一种新方法替代手术流产。米非司酮发展很快,但仅在少数国家应用。氨甲喋呤50mg/m~2肌注配伍米索前列醇(简称米索)800μg阴道放置,中止<56 d或≤63 d妊娠的有效率>90％。本文对妊娠≤63 d妇女口服氨甲喋呤50mg,并于第3、4 d或第5 d阴道放置米索,进行中止妊娠的研究。 研究对象>18岁,妊娠≤63 d,询问病史、体检、查验血色素、白细胞、血小板、血型、Rh因子、肌酐和转氨酶,阴道超声波估计孕龄。口服氨甲喋呤50mg,并随机于第3、4 d或第5 d阴道放置米索800μg。若48 h未流产,则再次放置米索800μg,仍未流产者,于首次用药后4 d最后放置米索800μg 48 h, Abortion is an important cause of death among women in the world and there is an urgent need for a new alternative to surgical abortion. Mifepristone develops rapidly, but only in a few countries. Methotrexate 50mg / m ~ 2 intramuscular injection of misoprostol (referred to as misoprostol) 800μg vaginal placement, termination of <56 d or 63d pregnancy efficiency> 90%. In this paper, methotrexate 50 mg was given orally to women 63 days of pregnancy, and misoprostol was administered vaginally on day 3, 4, or 5, to study the termination of pregnancy. Subjects> 18 years of age, 63 days of pregnancy, history, physical examination, examination of hemoglobin, white blood cells, platelets, blood type, Rh factor, creatinine and transaminase, vaginal ultrasound to estimate gestational age. Oral methotrexate 50mg, and randomized in the 3rd or 4th d or vaginal 5d misoprostolysis 800μg. If abortion did not occur after 48 hours, 800 μg of misoprostol was again placed and no abortion was still reported. 800 μg of misoprostol 800 μg was placed 4 days after the first dose,