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目的通过分组对比研究,探讨妊娠期糖尿病(GDM)合并亚临床甲状腺功能减退症(SCH)的发病状况及其对妊娠结局的影响。方法以2013年6月~2014年12月在新疆医科大学第一附属医院分娩的孕妇为研究对象,根据病况性质分为GDM+SCH组(66例)、GDM组(1 092例)、SCH组(147例)及对照组(1 000例),比较4组妊娠结局。结果 SCH患者中GDM发生率为44.90%,GDM+SCH组妊娠期高血压疾病、妊娠期蛋白尿、早产、胎儿低体重发生率及剖宫产率均高于其他3组(P<0.05)。结论 GDM与SCH可互相影响并加重患者病情发展,影响妊娠结局。在临床工作中,应重视糖代谢异常孕妇甲状腺功能的筛查,以减少母儿并发症。
Objective To investigate the incidence of gestational diabetes mellitus (GDM) combined with subclinical hypothyroidism (SCH) and its effect on pregnancy outcome through group comparison study. Methods The pregnant women who delivered at the First Affiliated Hospital of Xinjiang Medical University from June 2013 to December 2014 were divided into GDM + SCH group (66 cases), GDM group (1092 cases) and SCH group (147 cases) and control group (1000 cases). The pregnancy outcomes were compared between the 4 groups. Results The incidence of GDM was 44.90% in SCH patients. The incidence of gestational hypertension, gestational proteinuria, premature birth, low birth weight and cesarean section rate in GDM + SCH group were higher than those in other three groups (P <0.05). Conclusion GDM and SCH can affect each other and aggravate the patient’s condition and affect pregnancy outcome. In clinical work, should pay attention to screening of pregnant women with abnormal glucose metabolism thyroid function, in order to reduce the complications of mother and child.