【摘 要】
：
The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the role
【机 构】
：
Guangdong Provincial Key laboratory of Tumor Immunotherapy, School of Basic Medical Sciences, Cancer
论文部分内容阅读
The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclear. Here we demonstrate that the knockdown of HERC4 in human breast cancer cells dramatically suppressed their proliferation, survival, migration, and tumor growth in vivo, while the overexpression of HERC4 promoted their aggressive tumorigenic activities. HERC4 is a new E3 ligase for the tumor suppressor LATS1 and destabi-lizes LATS1 by promoting the ubiquitination of LATS1. miRNA-136-5p and miRNA-1285-5p, expression of which is decreased in human breast cancers and is inversely correlated with the prognosis of breast cancer patients, are directly involved in suppressing the expression of HERC4. In summary, we discover a miRNA-HERC4-LATS1 pathway that plays important roles in the patho-genesis of breast cancer and represents new therapeu-tic targets for human breast cancer.
其他文献
We recently reported an unconventional mechanism by which miRNAs inhibit HIV-1 viral production.This occurs when miRNAs bind nonspecifically to the viral struct
Development of ovarian cancer involves the co-evolution of neoplastic cells together with the adjacent microenvironment.Steps of malignant progression including
Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a biologically important modification that is involved in embryoni
This phase Ⅰ clinical trial (NCT01935843) is to evaluate the safety,feasibility,and activity of chimeric antigen receptor-engineered T cell (CART) immunotherap
Leukocyte differentiation antigens (LDAs) play important roles in the immune system,by serving as surface markers and participating in multiple biological activ
Aberrant regulation of miRNA genes contributes to pathogenesis of a wide range of human diseases,including cancer.The TAR DNA binding protein 43 (TDP-43),a RNA/
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and a significant global health problem with substantial rise in
美国密歇根州奥克兰大学历史系主任伯纳德·托马斯先生(Bernard Thomas)向1988年6月在北京召开的“纪念《西行漫记》发表五十周年学术讨论会”提交了题为《谈谈斯诺成功的若