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目的:探讨甲状腺浆细胞瘤的病理学特点及临床表现。方法:对1例甲状腺浆细胞瘤进行组织学表现、免疫组化染色观察及文献复习。结果:组织学特点:肿瘤细胞成分单一,大多数为分化较为成熟的肿瘤性浆细胞,胞核圆形或卵圆形,大小较一致,常偏位,染色质呈车辐状或钟面状。免疫组化特点:肿瘤细胞表达CD20(++)、CD79a(+)、CD38(++)、CD138(+)、κ链(++)。结论:甲状腺浆细胞瘤是甲状腺一种少见的肿瘤,应同炎症反应的浆细胞增生及低分化癌、淋巴瘤、髓样癌等相鉴别,可以通过免疫组化染色及形态学观察进行鉴别诊断。
Objective: To investigate the pathological features and clinical manifestations of thyroid plasmacytoma. Methods: One case of thyroid plasmacytoma was studied by histological examination, immunohistochemical staining and literature review. Results: Histological features: single tumor cells, most of the more mature differentiated tumor cells, round or oval nucleus, the size of the more consistent, often misplaced, chromatin was car-shaped or bell-shaped . Immunohistochemical features: tumor cells express CD20 (++), CD79a (+), CD38 (++), CD138 (+), κ chain (++). Conclusion: Thyroid plasmacytoma is a rare tumor of the thyroid gland. It should be differentiated from inflammatory cell hyperplasia and poorly differentiated carcinoma, lymphoma and medullary carcinoma, and can be differentially diagnosed by immunohistochemical staining and morphological observation .