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目的 :探讨原发腹膜后黏液囊腺癌(primary retroperitoneal mucinous cystadenocarcinoma,PRMC)患者的临床和病理组织学特征。方法:应用苏木精-伊红(HE)及免疫组织化学染色观察2例PRMC患者肿瘤的组织病理学特征,并结合相关文献进行分析。结果:2例患者经盆腔CT检查发现腹膜后巨大囊性占位。手术标本的病理检查显示,肿块的组织学形态为纤维囊壁组织衬覆增生的黏液柱状上皮,伴细胞内和(或)细胞外黏液,乳头状和(或)筛状结构,细胞异型性明显,伴间质毁损性浸润;肿瘤细胞CK7、CK20、β-catenin阳性,p53不同程度阳性,PR、ER和糖类抗原125阴性。结论:PRMC是临床罕见的肿瘤,检测肿瘤组织中β-catenin和p53的表达可能有助于鉴别。手术完整切除肿瘤后,患者的预后较好。
Objective: To investigate the clinical and histopathological features of primary retroperitoneal mucinous cystadenocarcinoma (PRMC) patients. Methods: Histopathological features of 2 PRMCs were observed by hematoxylin-eosin (HE) and immunohistochemical staining, and analyzed with related literatures. Results: Two cases of post-retroperitoneal cystic mass examination by pelvic CT examination. Pathological examination of the surgical specimens showed that the histological morphology of the lumps was muco-columnar epithelium with fibrous cyst wall tissue proliferation, with intracellular and / or extracellular mucus, papillary and / or sieve-like structures with obvious atypia , Accompanied by destructive infiltration of interstitium; tumor cells CK7, CK20, β-catenin positive, p53 to varying degrees, PR, ER and carbohydrate antigen 125 negative. Conclusion: PRMC is a rare clinical tumor. Detecting the expression of β-catenin and p53 in tumor may be useful in differential diagnosis. After the complete resection of the tumor, the patient’s prognosis is good.