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很多证据说明单纯疮疹2型病毒(HSV-2)在生殖器癌起作用,例如流行病学研究证明宫颈有癌前和癌病变的妇女与配对对照者相比,血清中抗HSV-2抗体效价较高,免疫细胞化学研究显示人宫颈癌前和癌细胞中含HSV遗传物质并表达某些与HSV-2相关的多肽.用超免疫和单特异性抗血清在相当多有重度结构不良(dysplasia)、原位癌和浸润性鳞癌妇女的宫颈活检细胞中发现HSV-2早期无结构多肽-Vpl43.
There is ample body of evidence that HSV-2 plays a role in genital cancer. For example, epidemiological studies have shown that women with cervical precancerous and cancerous lesions have a comparable anti-HSV-2 antibody response to matched controls Immunocytochemistry studies have shown that HSV genetic material is present in pre-cancerous and cancerous cells and that some of the polypeptides associated with HSV-2 are expressed in hyperimmunized and monospecific antisera in quite a few patients with severe structural dysfunction dysplasia), HSV-2 early unstructured polypeptide-Vpl43 was found in cervical biopsy cells of women with carcinoma in situ and invasive squamous cell carcinoma.