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RNA干扰技术以其特异性和高效性抑制基因表达,已经成为研究基因功能的重要工具。它能够沉默同源基因的表达,在肿瘤的基因靶向治疗中发挥的作用日趋明显。最近,RNA干扰技术应用于结肠癌靶向基因沉默为结肠癌的基因靶向治疗开辟了新的途径。现就RNA干扰技术在结肠癌基因靶向治疗的研究进行综述。
RNA interference technology, with its specificity and high efficiency to inhibit gene expression, has become an important tool for studying gene function. It can silence the expression of homologous genes and play a more and more significant role in gene therapy of tumors. Recently, the application of RNA interference technology in colon cancer targeted gene silencing has opened a new avenue for gene therapy of colon cancer. RNA interference technology in the colon cancer gene therapy research are reviewed.