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目的 :检测睡眠呼吸暂停综合征 (SAS)患者血浆中NO水平 ,分析SAS患者睡眠时的呼吸暂停指数 (AI)、平均血氧饱和度 (SpO2 )与NO水平的关系。探讨SAS患者体内NO水平变化的可能原因及对机体的影响。方法 :应用硝酸还原酶法测定血浆NO水平。用澳大利亚产Autoset和多导睡眠仪 (PSG)检测SAS患者AI、SpO2 。结果 :SAS患者血浆NO水平与正常组比较显著增高 (男性P <0 .0 0 1 ,女性P <0 .0 1 )。NO含量与AI无相关性 (r=0 .0 63) ,与SpO2 呈负相关 (r=- 0 .61 8)。结论 :SAS血浆NO水平升高可能与患者呼吸系统炎症有关。
Objective: To detect plasma NO levels in patients with sleep apnea syndrome (SAS) and to analyze the relationship between apnea index (AI) and mean oxygen saturation (SpO2) and NO levels during SAS sleep. To explore the possible causes of NO level changes in SAS patients and the impact on the body. Methods: Nitric acid reductase method was used to determine plasma NO level. SAS and SpO2 were measured in Australian patients with Autoset and polysomnography (PSG). Results: The plasma level of NO in SAS patients was significantly higher than that in normal controls (P <0.01 for males and P <0.01 for females). There was no correlation between NO level and AI (r = 0.603) and negatively correlated with SpO2 (r = -0.661). Conclusions: Elevated NO levels in SAS plasma may be related to respiratory inflammation in patients.