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目的通过测定外周血未染色大细胞比率(LUC%),以期提高骨髓增生异常综合征(MDS)的早期诊断率。方法选取我院58例确诊为MDS的患者,并设30例对照病例,比较外周血中LUC%和骨髓形态学报告。结果 58例MDS患者中54例(93.1%)外周血LUC%高于正常,其中有45例(83.3%)经初次骨髓穿刺诊断为MDS,9例(16.7%)经2～3次骨髓穿刺诊断为MDS。对照组30例中有1例(3.3%)外周血LUC%高于正常者。结论外周血LUC%的增高有早期诊断MDS的价值。
Objective To improve the early diagnosis rate of myelodysplastic syndrome (MDS) by measuring the ratio of non-stained macrophages (LUC%) in peripheral blood. Methods Fifty-eight patients diagnosed as MDS in our hospital were selected and 30 control cases were included. The LUC% in peripheral blood and morphology of bone marrow were compared. Results The LUC% of peripheral blood in 54 cases (93.1%) of 58 patients with MDS was higher than normal. Among them, 45 cases (83.3%) were diagnosed as MDS by primary bone marrow aspiration and 9 cases (16.7%) were diagnosed by bone marrow aspiration For MDS. One out of 30 patients (3.3%) in the control group had higher LUC% in peripheral blood than in normal subjects. Conclusion The increase of LUC in peripheral blood has the value of early diagnosis of MDS.