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目的:探讨黄连解毒汤对高脂大鼠血脂水平及炎症因子的影响。方法:选取60只雄性SD大鼠,随机分为常规饲料组、高脂饲料组、常规饲料加抗生素组、高脂饲料加抗生素组、中药低剂量组及中药高剂量组。常规饲料组与高脂饲料组均给予进食常规饲料及高脂饲料6周,中药低、高剂量组在喂食6周高脂饲料后,分别给予低、高剂量中药,并连续灌胃2周;抗生素组则分别进食常规饲料和高脂饲料6周后给予抗生素2周。8周后观察各组小鼠的体质量、血脂水平(TC)、肿瘤坏死因子(TNF-a)、白细胞介素~6水平。结果:黄连解毒汤可显著降低TNF-a及IL-6水平,与常规饲料组和高脂饲料组比较,差异有统计学意义(P<0.05),对血清胆固醇改善明显,与治疗前比较,差异有统计学意义(P<0.05)。结论:黄连解毒汤可显著改善高脂血症大鼠血脂水平,且能显著抑制炎症因子的表达。
Objective: To investigate the effect of Huanglian Jiedu Decoction on blood lipids and inflammatory factors in hyperlipidemic rats. Methods: Sixty male Sprague-Dawley rats were randomly divided into routine feed group, high fat diet group, conventional feed plus antibiotic group, high fat diet plus antibiotic group, low dose Chinese medicine group and high dose Chinese medicine group. The normal and high-fat diet groups were fed with normal diet and high-fat diet for 6 weeks. The low and high dose groups were given low-dose and high-dose of traditional Chinese medicine after 6 weeks of high-fat diet respectively and were given continuous gavage for 2 weeks. Antibiotics were given antibiotics for 6 weeks after 6 weeks of routine and high-fat diet respectively. After 8 weeks, the body weight, blood lipid level (TC), tumor necrosis factor (TNF-a) and interleukin-6 levels in each group were observed. Results: Huanglian Jiedu Decoction could significantly decrease the levels of TNF-a and IL-6. Compared with the normal diet group and the high-fat diet group, the difference was statistically significant (P <0.05) and the serum cholesterol significantly improved. The difference was statistically significant (P <0.05). Conclusion: Huanglian Jiedu Decoction can significantly improve blood lipid levels in hyperlipidemic rats, and can significantly inhibit the expression of inflammatory cytokines.