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腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,D-IBS)是临床常见的功能性肠道疾病,给患者的生活和工作带来诸多不便。痛泻要方作为中医古代著名方剂,能够明显减轻D-IBS患者的腹痛、腹泻症状,提高其生活和工作质量,但其治疗的确切机制尚不明确,本文从5-羟色胺及嗜铬素A(chromogranin A,CGA)相关离子通道转运机制的角度出发,探讨痛泻要方对D-IBS结肠黏膜离子通道的影响,以期为后续的临床与基础研究提供可靠的依据。
Diarrhea-predominant irritable bowel syndrome (D-IBS) is a common clinical functional bowel disease, which brings many inconveniences to the life and work of patients. Tong Xie Yao Fang as an ancient Chinese well-known prescription, can significantly reduce the D-IBS patients with abdominal pain, diarrhea symptoms and improve their quality of life and work, but the exact mechanism of treatment is not clear, this article from 5-hydroxytryptamine and chromogranin A To investigate the effect of Tongxie Yaofang on colonic mucosal ion channels of D-IBS in order to provide a reliable basis for the follow-up clinical and basic research.