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目的研究甲状腺乳头状微小癌(PTMC)合并桥本甲状腺炎(HT)的临床病理特点,为临床诊治提供参考。方法:收集我院2010年10月-2013年9月收治并经手术病理证实为PTMC患者的临床病理资料,以是否合并HT分组比较,并进行回顾性分析。结果 119例PTMC中,男女比例1:2.6,年龄(44.4±12.4)岁,术前甲状腺功能正常者97例(81.5%),肿瘤平均最大径(6.8±2.3)mm,有颈部淋巴结转移36例(30.3%),合并HT 41例(34.5%)。与未合并HT组相比,合并HT组中女性更多,发病年龄较小,术前促甲状腺激素(TSH)较高,肿瘤最大径较小,相互比较存在统计学差异(P<0.05)。合并HT组的颈部淋巴结转移率(36.6%)稍高于未合并HT组(26.9%),且与年龄、肿瘤最大径显著相关。结论 PTMC合并HT在较年轻的女性、术前血TSH水平偏高者中较常见。起病年龄较小、癌灶最大径≥7.0 mm时更易发生颈淋巴结转移。
Objective To study the clinicopathological features of thyroid papillary microcarcinoma (PTMC) combined with Hashimoto’s thyroiditis (HT) and provide a reference for clinical diagnosis and treatment. Methods: The clinical and pathological data of patients with PTMC who were admitted to our hospital from October 2010 to September 2013 were retrospectively analyzed. Results Among 119 PTMCs, the ratio of male to female was 1: 2.6, and the age was (44.4 ± 12.4) years. Preoperative thyroid function was normal in 97 cases (81.5%) and the average tumor size was (6.8 ± 2.3) mm. Cases (30.3%), 41 cases of HT (34.5%). Compared with the non-combined HT group, there were more females, younger age of onset, higher thyroid-stimulating hormone (TSH) and smaller maximum diameter of tumor in the combined HT group (P <0.05). The rate of cervical lymph node metastasis (36.6%) in HT group was slightly higher than that in HT group (26.9%), which was significantly associated with age and tumor diameter. Conclusions PTMC combined HT is more common in younger women and preoperative TSH levels. The younger age of onset, the maximum diameter of cancer ≥ 7.0 mm is more likely to cervical lymph node metastasis.