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采用双盲双模拟、随机对照法，对比研究受试药卡维地洛片和对照药阿替洛尔对２０５例轻、中度原发性高血压患者的降压效果及药物不良反应。治疗４周后，卡维地洛使平均坐位收缩压及舒张压分别下降１０．８％和１２．７％，阿替洛尔分别下降１３．３％和１３．４％；两药总有效率分别为８５．１％及７８．８％。卡维地洛和阿替洛尔均能明显降低心率，但卡维地洛降低幅度较小。两药的临床疗效无显著性差异，日服一次，均可较平稳地控制２４ｈ血压。卡维地洛治疗后６个月，降压疗效保持，并有逆转肥厚心肌、改善血流动力学的作用。常见药物不良反应为乏力、头晕等，在服药过程中逐渐减轻，无因药物不良反应而终止试验者。结果提示，卡维地洛治疗原发性高血压，具有长期用药安全，耐受性好，疗效稳定等优点，与阿替洛尔比较，卡维地洛对心率和生化代谢影响小，是较好的抗高血压药物之一
A double-blind, double-dummy, randomized controlled trial was conducted to compare the antihypertensive efficacy and adverse drug reactions of 205 cases of mild to moderate essential hypertension with the combination of carvedilol and atenolol. After 4 weeks of treatment, carvedilol decreased average sitting systolic and diastolic blood pressure by 10.8% and 12.7%, while atenolol decreased by 13.3% and 13.4% respectively. The total effective rate Respectively at 85.1% and 78.8%. Carvedilol and atenolol significantly reduced heart rate, but carvedilol decreased less. The clinical efficacy of two drugs no significant difference, on a daily basis, can be more stable control of 24h blood pressure. Six months after carvedilol treatment, antihypertensive efficacy was maintained, and there was reversal of hypertrophic myocardium to improve hemodynamic effects. Common adverse drug reactions to fatigue, dizziness, etc., gradually reduce the medication, no adverse reactions due to drug termination of the test. The results suggest that carvedilol treatment of essential hypertension, with long-term medication safety, tolerability, efficacy and stability, compared with atenolol, carvedilol on the heart rate and biochemical metabolism of small, is more Good anti-hypertensive drugs