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1908年 Shauahan 首先报告全身性强直一陈挛性发作引起急性肺水肿,包括3例儿童和5例死亡在内共11例.2年后Ohlmacher 报告5例严重的发作后肺水肿(PIPE).此后,直到1965年有1例报道后,本病在英文文献上未被重视,而且无论以前或后来的报告中均未见儿童发病经过或需气管插管病例的记载.例1,9岁男孩,有局部发作继而全身性大发作史,曾接受卡马西平(CBZ)和苯妥英(PHT)治疗,此次全身性强直一阵挛发作持续5分钟,呕吐时并未吸入呕吐物,随即出现呼吸窘迫,咳粉红色泡沫样痰。入院查体:呼吸轻度困难,神志清醒,体温37℃,脉搏136次/分,血压128/64mmHg,双肺底呼吸音减低伴有
In 1908, Shauahan first reported acute pulmonary edema caused by tetanic and clonic episodes in 11 patients, including 3 children and 5 deaths. Five years later Ohlmacher reported 5 severe post-episode pulmonary edema (PIPE) The disease was not valued in the English literature until 1 case was reported in 1965. No cases of child onset or tracheal intubation have been documented in any previous or subsequent reports.1,9 year old boy, A partial episode of systemic seizures, CBZ and PHT treatment, the generalized tonic clonic seizure continued for 5 minutes, vomiting did not inhaled vomit, then there was respiratory distress, Cough pink foam sputum. Admission examination: mild breathing difficulty, conscious, body temperature 37 ℃, pulse 136 beats / min, blood pressure 128 / 64mmHg, accompanied by a reduction of the bottom of the lung breath sounds