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本文通过对24只北京大耳兔,左肝叶切除手术前后的血液流变学对比观察,结果显示家兔术后有明显的血液流变学变化:血细胞压积下降非常显著,P<0.001。而全血粘度随剪切率的升高,比术前下降的幅度逐渐缩小,3.6 ̄(s-1)时P<0.01,36 ̄(s-1)时P<0.05,到210 ̄(s-1)时则无明显差异,P>0.05,这说明红细胞的刚性有显著增强;血小板聚集,纤维蛋白原、血浆粘度及血沉在术后均极显著升高,P值均<0.001。实验结果提示:家兔在手术后这种血液流变性质的异常及高凝现象的存在,直接印证了临床外科术后多现血瘀证的观察结论,并为临床外科术后采用活血化瘀辨证治则提供了实验研究依据。
In this paper, we compared the hemorheology between 24 rabbits and left hepatic lobectomy before and after the resection. The results showed that there was obvious hemorheological changes in rabbits after operation: the decrease of hematocrit was very significant (P <0). 001. The whole blood viscosity with the shear rate increased, decreased gradually than the preoperative, 3.6 (s-1) P <0.01, 36 (s-1) P <0.05 , There was no significant difference at 210 ~ (s-1), P> 0.05, indicating that the rigidity of erythrocytes was significantly increased; platelet aggregation, fibrinogen, plasma viscosity and erythrocyte sedimentation rate were significantly increased after surgery, P <0.001. The experimental results suggest that the existence of abnormal blood rheology and hypercoagulation in rabbits after surgery directly confirms the observation conclusion of more blood stasis syndrome after clinical surgery, Syndrome Differentiation provides the basis for experimental research.