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[目的]探讨CXCR4在食管癌中的表达及意义。[方法]应用免疫组织化学方法检测82例食管癌组织、20例癌旁食管组织中CXCR4的表达。[结果]CXCR4在癌旁食管组织无表达,在82例食管癌组织中的阳性表达率为64.6%(53/82)。CXCR4表达与食管癌患者的年龄、性别无关,而与分化程度、TNM分期、浸润深度、组织学类型和淋巴结转移有关。[结论]CXCR4在食管癌中高表达,CXCR4可能是促进食管癌侵袭和转移的一个重要分子。
[Objective] To investigate the expression of CXCR4 in esophageal cancer and its significance. [Method] Immunohistochemistry was used to detect the expression of CXCR4 in 82 cases of esophageal cancer tissues and 20 cases of paracancerous esophageal tissues. [Results] CXCR4 was not expressed in the para-cancerous esophageal tissues, and the positive rate of CXCR4 in 82 esophageal cancer tissues was 64.6% (53/82). CXCR4 expression in esophageal cancer patients age and sex has nothing to do, but with the degree of differentiation, TNM stage, depth of invasion, histological type and lymph node metastasis. [Conclusion] CXCR4 is overexpressed in esophageal cancer, and CXCR4 may be an important molecule to promote the invasion and metastasis of esophageal cancer.