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寻找新的疟疾长效预防药物是当前疟疾防治研究中的重要课题之一。我校抗疟药研究组合成的新药——磷酸羟基喹哌,经过前几年的现场验证,证明对恶性疟和间日疟的疗效良好,副反应少,而且对抗氯喹恶性疟的疗效同样满意。但是,此药对疟疾的预防效果如何,尚未进行过验证。为此,我们于1977年7月中旬至10月底在安徽省淮南市往年疟疾发病率较高的李一矿,进行对间日疟的预防效果观察。现将结果报告如下。
Finding new malaria long-acting preventive drugs is one of the important topics in the research of malaria control. Our new anti-malarial drug research team composed of a new drug - hydroxyl hydroxyquipir, after a few years of on-site verification, proved effective against falciparum malaria and vivax malaria, fewer side effects, but also against the efficacy of chloroquine falciparum malaria are equally satisfied . However, the drug’s preventive effect on malaria has not been verified. For this reason, we observed the preventive effect of P. vivax in Li Yi Mine, which had a high incidence of malaria in Huainan, Anhui Province in the middle of July 1977 to the end of October 1977. The results reported below.