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作者报道~(124)I标记的单克隆抗体-丝裂霉素C结合物在荷人胃癌裸鼠体内的定位及分布结果。在结合物制备及碘标记过程中,抗体活性无明显丧失,结合物能较好地定位于肿瘤组织,腹腔注射标记结合物141h肿瘤组织放射性比度与6种脏器的平均放射性比度的比值达5.56,与未修饰抗体分布状况相近。
The authors reported the localization and distribution of ~(124)I-labeled monoclonal antibody-mitomycin C conjugates in nude mice bearing human gastric cancer. During the preparation of conjugates and iodine labeling, there was no apparent loss of antibody activity, and the conjugates could be better localized in the tumor tissue. The ratio of radioactivity of tumor tissue conjugated 141h to the mean radioactivity of six organs in the peritoneal cavity was markedly Up to 5.56, similar to the distribution of unmodified antibodies.