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通过观察各型病毒性肝炎及肝硬化患者血清Ⅰ型前胶原羧基端肽 (PICP)及表皮生长因子 (EGF)水平 ,以评价其在肝纤维化中的临床意义。本文采用放射免疫分析方法测定了 134例病毒性肝炎患者和 30名正常人(对照组 )的血清PICP及ECF水平。结果表明急性肝炎组两指标与对照组相比无显著差异 (P >0 .0 5 ) ,而慢性肝炎轻中型组、慢性肝炎重型组及肝硬化组两指标与对照组相比 ,均有显著性差异 (P <0 .0 5 - 0 .0 1) ,其中慢性肝炎重型组两指标水平最高。以上结果说明 ,测定血清PICP及EGF水平可以反映肝纤维化程度及慢性肝病的活动度 ,是临床上判断肝病进展及预后的一项参考指标
To observe the clinical significance of serum level of procollagen carboxyterminal peptide (PICP) and epidermal growth factor (EGF) in patients with various types of viral hepatitis and cirrhosis and to evaluate its clinical significance in liver fibrosis. In this paper, serum PICP and ECF levels in 134 patients with viral hepatitis and 30 healthy controls (control group) were determined by radioimmunoassay. The results showed that there was no significant difference between the acute hepatitis group and the control group (P> 0.05), while the chronic hepatitis group, the chronic hepatitis group and the cirrhosis group had significant difference compared with the control group The difference was significant (P <0.05-0.01), in which the two indicators of chronic severe hepatitis group had the highest level. The above results show that the determination of serum PICP and EGF levels can reflect the degree of liver fibrosis and chronic liver disease activity is a clinical reference to determine the progress of liver disease and prognosis