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研究表明,辐照致弱血吸虫尾蚴疫苗能够诱导宿主产生较高的免疫保护作用,是所有血吸虫候选疫苗中保护力最强的,且辐照致弱尾蚴在宿主体内不能发育成熟,不会对宿主造成严重的病理损害。单性感染的血吸虫同样不能在宿主体内发育成熟,其发育状态停留在童虫阶段,也不会对宿主造成严重的病理损害,在童虫状态下对宿主持续进行的免疫刺激,是否也能诱导宿主对继发血吸虫病产生较高的免疫保护作用呢?为此,本研究通过让宿主携带单性血吸虫雄虫的带虫免疫方式来检测其对继发血吸虫病的影响。选用雄性血吸虫尾蚴感染BALB/c小鼠(100条/只),于单性血吸虫尾蚴攻击后第5、7 w用吡喹酮进行治疗(300mg/kg),第9 w进行雌雄血吸虫混合尾蚴攻击实验动物(40条/只),第15 w剖杀实验动物,收集宿主荷虫、宿主肝卵负荷、肝卵孵化、宿主肝单卵肉芽肿体积数据,并检测宿主血清特异性抗体变化趋势。结果表明单性带虫免疫可以引起宿主肝虫卵孵化率及组织病理损伤显著降低,对宿主有一定的免疫保护效果。
Studies have shown that irradiated attenuated Schistosoma japonicum cercariae vaccine can induce host to produce a higher immune protection, is the strongest protection of all schistosome vaccine candidates, and radiation-induced cercariae in the host can not mature, will not host Cause serious pathological damage. Schistosoma japonicum also can not mature in the host, its developmental state stays in the stage of the squirrel, it will not cause serious pathological damage to the host, in the state of the sperm, the host continues the immune stimulation, can also induce Host to secondary schistosomiasis have a higher immune protection effect? To this end, the study by letting the host carrying schistosoma japonicum adult worm immunization methods to detect its impact on secondary schistosomiasis. BALB / c mice were infected with cercariae of Schistosoma japonicum (100 pcs / mouse), treated with praziquantel (300mg / kg) on the 5th and 7th wk after challenge with Schistosoma japonicum cercariae, and mixed cercariae attack Experimental animals (40 / only), the first 15 w of experimental animals were dissected, host load, host liver egg load, liver egg hatching, host liver single egg granuloma volume data and detect serum host antibody-specific antibody trends. The results showed that the immunity of the unicornavirus could cause the hatching rate and the histopathological damage of the host hepatic worm to be significantly reduced, and had certain immunoprotective effect on the host.