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AIM:To investigate pulmonary involvement via pulmonaryfunction tests (PFT) and high-resolution computed tomocjraphy(HRCT) in patients with chronic hepatitis C virus (HCV) infection.METHODS:Thirty-four patients with chronic HCV infectionwithout diagnosis of any pulmonary diseases and 10 healthycases were enrolled in the study,PFT and HRCT wereperformed in all cases.RESULTS:A decrease lower than 80% of the predicted valuewas detected in vital capacity in 9/34 patients,in forcedexpiratory volume in one second in 8/34 patients,and in forcedexpiratory flow 25-75 in 15/34 patients,respectively.Carbonmonoxide diffusing capacity (DLCO) was decreased in 26/34patients.Findings of interstitial pulmonary involvement weredetected in the HRCT of 16/34 patients.Significant differencewas found between controls and patients with HCV infection infindings of HRCT (X~2=4.7,P=0.003).Knodell histologicalactivity index (KHAI) of 28/34 patients in whom liver biopsywas applied was 9.0±4.7.HRCT findings,PFT values and DLCOwere not affected by KHAI in patients with HCV infection.Inthese patients,all the parameters were related with age.CONCLUSION:We suggest that chronic hepatitis C virusinfection may cause pulmonary interstitial involvementwithout evident respiratory symptoms.
AIM: To investigate pulmonary involvement via pulmonaryfunction tests (PFT) and high-resolution computed tomocjraphy (HRCT) in patients with chronic hepatitis C virus (HCV) infection.METHODS: Thirty-four patients with chronic HCV infectionwithout diagnosis of any pulmonary diseases and 10 Acute lower rates than 80% of the predicted value was detected in vital capacity in 9/34 patients, in forcedexpiratory volume in one second in 8/34 patients, and in forcedexpiratory flow 25-75 in 15/34 patients, respectively.Carbonmonoxide diffusing capacity (DLCO) was decreased in 26/34 patients. Findings of interstitial pulmonary involvement were detected in the HRCT of 16/34 patients. Differences betweenwas found between controls and patients with HCV infection infindings of HRCT (X ~ 2 = 4.7, P = 0.003) .Knodell histologicalactivity index (KHAI) of 28/34 patients in whom liver biopsywas applied 9.0 ± 4.7. HRTT findings, PFT va lues and DLCO were not affected by KHAI in patients with HCV infection. Inthese patients, all the parameters were related with age. CONCLUSION: We suggest that chronic hepatitis C virus infection may cause pulmonary interstitial involvementwithout evident respiratory symptoms.