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目的分析新生儿高胆红素血症的血清学试验结果,探讨孕妇产前不规则抗体筛查的重要性和必要性。方法回顾性分析2014年8月-2015年3月该院742例新生儿高胆红素血症的血清学试验,即新生儿红细胞直接抗人球蛋白试验、血清游离试验及新生儿红细胞释放试验。结果 262例被诊断为母婴血型不合导致的新生儿溶血病(HDN),其中ABO溶血病占254例,母亲O型-新生儿A型占162例,母亲O型-新生儿B型占92例;Rh溶血病占8例,其中2例由抗-D引起,6例由抗-c、抗-E、抗-C、抗-e引起。结论孕期筛查不规则抗体,对提前预防HDN有一定的临床价值。
Objective To analyze the serological test results of neonatal hyperbilirubinemia and explore the importance and necessity of screening prenatal irregular antibodies in pregnant women. Methods A retrospective analysis of 742 neonates with hyperbilirubinemia from August 2014 to March 2015 was performed in this hospital, namely, the direct neonatal erythrocyte anti-human globulin test, serum free test and neonatal red blood cell release test . Results 262 cases were diagnosed as neonatal hemolytic disease (HDN) due to maternal and neonatal incompatibility, of which 254 cases were ABO hemolytic disease, 162 cases were type O-mothers with type A neonates, 162 were type A neonates with mothers type O-92 Cases; Rh hemolytic disease accounted for 8 cases, of which 2 cases were caused by anti-D, 6 cases by anti-c, anti-E, anti-C, anti-e cause. Conclusion The screening of irregular antibodies during pregnancy has some clinical value in preventing HDN in advance.